Food Science & Technology, Tokyo University of Narine Science and Technology Food Chemistry and Functional Nutrition





  • K. Yoshinaga, Y. Usami, A. Y. Kiriake, H. Shikano, S.Taira, R. Nagasaka, S. Tanaka, N. Gotoh, Visualization of dietary docosahexaenoic acid in whole-body zebrafish using matrix-assisted laser desorption/ionization mass spectrometry imaging, The Journal of Nutritional Biochemistry, 100 (108897), 2021


  • R. Nagasaka, H. Nakachi, Y. Onodera, Y. Ishikawa, T. Ohshima, Leptin promotes the fat preference associated with low-temperature acclimation in mice, Bioscience, Biotechnology, and Biochemistry84(6) 1250-1258, 2020.


  • R. Nagasaka, A. Harigaya, T. Ohshima, Effect of proteolysis on meat quality of brand fish, red sea bream Pagrus major, Food Science and Technology Research24(3) 465-473, 2018.
  • R. Nagasaka, E. Swist, K. Sarafin, C. Gagnon, I. Rondeau, I. Massarelli, W. Cheung, P. Laffey, S.P.J. Brooks, W.M.N. Ratnayake, Low 25-hydroxyvitamin D levels are more prevalent in Canadians of South Asian than European ancestry inhabiting the National Capital Region of Canada, PLoS ONE 13(12): e0207429, 2018. 


  • J. Pahila, H. Kaneda, R. Nagasaka, T. Koyama, T. Ohshima, Effects of ergothioneine-rich mushroom extracts on lipid oxidation and discoloration in salmon muscle stored at low temperatures, Food Chemistry, 233, 273-281, 2017.


  • C-W. Xiao, CM. Wood, E. Swist, R. Nagasaka, K. Sarafin, C. Gagnon, et al. Cardio-Metabolic Disease Risks and Their Associations with Circulating 25-Hydroxyvitamin D and Omega-3 Levels in South Asian and White Canadians. PLoS ONE 11(1): e0147648. doi:10.1371/journal.pone.0147648, 2016.
  • G. Kaneko, H. Shirakami, Y. Hirano, M. Oba, H. Yoshinaga, A. Khieokhajonkhet, R. Nagasaka, H. Kondo, I. Hirono, H. Ushio, Diversity of lipid distribution in fish skeletal muscle, Zool. Sci.  33(2):170-178. 2016 doi:


  • R. Nagasaka, Y. Ishikawa, T. Inada, T. Ohshima,Depigmenting Effect of Winter Medicinal Mushroom, Flammulna velutipes (Higher  Basidiomycetes) on Melanoma Cells,Int. J. Med. Mush. 17 (6), 511-520, 2015.
  • A. Harigaya, R. Nagasaka, T. Ohshima, Roles of apoptosis and autophagy on the texture of red sea bream muscle,  KnE Life Sciences, 135-382015.
  • G. Kaneko, H. Shirakami, Y. Hirano, M. Oba, H. Yoshinaga, A. Khieokhajonkhet, R. Nagasaka, H. Kondo, I. Hirono, H. Ushio, Diversity of lipid distribution in fish skeletal muscle, Zool. Sci. 33, 170-178.


  • R. Nagasaka, C. Gagnon, E. Swist, I. Rondeau, I. Massarelli, W. Cheung, W.M.N. Ratnayake, EPA and DHA status of South Asian and White Canadians living in the National Capital Region of Canada, Lipids, 49, 1057-1069.
  • S. Yamada, T. Koyama, H. Noguchi, Y. Ueda, R. Kitsuyama, H. Shimizu, A. Tanimoto, K. Wang, A. Nawata, T. Nakayama, Y. Sasaguri, T. Satoh, Marine Hydroquinone zonarol prevents inflammation and apoptosis in dextran sulfate sodium-induced mice ulcerative colitis, PLOS ONE10.1371/journal.pone.0113509, 2014.


  • H. Ushio, R. Nagasaka, Utilization of Biological Responses of Fish and Shellfish for Improving Seafood Qualities,Aqua-BioScience Monographs, 6 (3), 91-98, 2013.
  • Y. Han, G. Kaneko, R. Nagasaka H. Kondo, I. Hirono, S. Takahashi, S. Watabe, H. Ushio, Distribution of adipocyte-related cells in skeletal muscle of rainbow trout Oncorhynchus mykiss. Fish. Sci. 79 (1), 143-148, 2013.
  • G. Kaneko, T. Yamada, Y. Han, Y. Hirano, A. Khieokhajonkhet, H. Shirakami, R. Nagasaka, H. Kondo, I. Hirono, H. Ushio, S. Watabe, Differences in lipid distribution and expression of peroxisome proliferator-activated receptor gamma and lipoprotein lipase genes in torafugu and red seabream. Gen. Comp. Endocrinol. 184, 51-60, 2013


  • T. H. Nguyen, R. Nagasaka, T. Ohshima, Effects of extracting solvents, cooking procedures and storage conditions on the contents of ergothioneine and phenolic compounds and antioxidative capacity of the cultivated mushroom, Flammulina velutipes. Int. J. Food Sci. Tech. 47, 1193–1205, 2012.
  • M. Shirosaki, T. Koyama, K. Yazawa. Suppressive effect of peach leaf extract on glucose absorption from the small intestine of mice. Biosci. Biotechnol. Biochem. 76(1), 89-94, 2012.
  • T. Koyama, M. Miyata, T. Nishimura, K. Yazawa. Suppressive effects by leaves of the Dypsis lutescens palm on fat accumulation in 3T3-L1 cells and fat absorption in mice. Biosci. Biotechnol. Biochem. 76(1), 189-192, 2012.
  • H. Kondo, S. Suda, Y. Kawana, I. Hirono, R. Nagasaka, G. Kaneko, H. Ushio, S. Watabe, Effects of feed restriction on the expression profiles of the glucose and fatty acid metabolism-related genes in rainbow trout Oncorhynchus mykiss muscle. Fish. Sci. 78 (6), 1205-1211, 2012.


  • K. Yazawa, K. Suga, A. Honma, M. Shirosaki, T. Koyama, Anti-inflammatory effects of seeds of the tropical fruit camu-camu (Myrciaria dubia). J. Nutr. Sci. Vitamino. 57(1), 104-107, 2011.
  • A. Honma, T. Koyama, K. Yazawa, Anti-hyperglycemic effects of the Japanese red maple Acer pycnanthum and its constituents the ginnalins B and C. J. Enzyme Inhibit. Med. Chem. 26(2), 176-180, 2011.
  • A. Ogawa, Y. Miyamae, A.i Honma, T. Koyama, K. Yazawa, H. Shigemori, Pycnalin, a new α-glucosidase inhibitor from Acer pycnanthum. Chem. Pharm. Bull. 59(5), 672-675, 2011.
  • J. Wu, K. Fushimi, S. Tokuyama, M. Ohno, T. Miwa, T. Koyama, K. Yazawa, K. Nagai, T. Matsumoto, H. Hirai, H. Kawagishi, Functional-Food constituents in the fruiting bodies of Stropharia rugosoannulata. Biosci. Biotechnol. Biochem. 75(8), 1631-1634, 2011.
  • J. Wu, J.H. Choi, M. Yoshida, H. Hirai, E. Harada, K. Masuda, T. Koyama, K. Yazawa, K. Noguchi, K. Nagasawa, H. Kawagishi, Osteoclast-forming suppressing compounds, gargalols A, B and C, from the edible mushroom Grifola gargal. Tetrahedron, 67(35), 6576-6581, 2011.
  • K. Ohara, Y. Kiyotani, A. Uchida, R. Nagasaka, H. Maehara, S. Kanemoto, M. Hori, H. Ushio, Oral administration of γ-aminobutyric acid and γ-oryzanol prevents stress-induced hypoadiponectinemia, Phytomedicine, 18 (8-9), 669-671, 2011.
  • R. Nagasaka, T. Yamsaki, A. Uchida, K. Ohara, H. Ushio, γ-Oryzanol recovers mouse hypoadiponectinemia induced by animal fat ingestion, Phytomedicine, 18 (8-9), 655-660, 2011.
  • R. Nagasaka, T. Kazama, H. Ushio, H. Sakamoto, K. Sakamoto, S. Satoh, Accumulation of gamma-oryzanol in teleost. Fish. Sci. 77, 431-438, 2011.
  • M.d. Shafiqul Islam, R. Nagasaka, K. Ohara, T. Hosoya, H. Ozaki, H. Ushio, M. Hori, Biological abilities of rice bran-derived antioxidant phytochemicals for medical therapy. Curr. Top. Med. Chem. 11 (14), 1847-1853, 2011.
  • H. Kondo, R. Suga, S. Suda, R. Nozaki, I. Hirono, R. Nagasaka, G. Kaneko, H. Ushio, S. Watabe, Expressed sequence tag analysis on adipose tissue of rainbow trout Oncorhynchus mykiss and tissue distribution of adiponectin, Gene, 485(1), 40-45, 2011.
  • γ―オリザノールの添加がアスタキサンチン含有飼料によるブリ切り身の変色抑制作用に及ぼす影響,長阪玲子,風間貴充,潮 秀樹,坂本浩志,坂本憲一,日水誌,77 (6), 1101-1104, 2011.


  • N. Maru, O. Ohno, T. Koyama, K. Yamada, D. Uemura, Papillamide, a novel fatty acid amide from the red alga Laurencia papillosa. Chem. Lett. 39, 366-367, 2010.
  • M. Miyata, T. Koyama, K. Yazawa, Water extract of Houttuynia cordata Thunb. leaves exerts anti-obesity effects by inhibiting fatty acid and glycerol absorption. J. Nutr. Sci. Vitaminol. 56, 150-156, 2010.
  • J.H. Choi, N. Abe, S. Kodani, K. Masuda, T. Koyama, K. Yazawa, M. Takahashi, H. Kawagishi, Osteoclast-forming suppressing compounds from the medicinal mushuroom Agrocybe chaxingu Huang (Agaricomycetideae). Int. J. Med. Mushrooms, 12, 151-155, 2010.
  • K. Washida, M. Miyata, T. Koyama, K. Yazawa, K. Nomoto, Suppressive effect of Yamato-mana (Brassica rapa L. oleifera group) constituent 3-butenyl glucosinolate (gluconapin) on postprandial hypertriglyceridemia in mice. Biosci. Biotech. Biochem. 74, 1286-1289, 2010.
  • K. Masuda, T. Kawaguchi, T. Koyama, T. Nishimura, H. Kawagishi, K. Yazawa, Osteoclast-forming suppressive compounds from Anoectochilus formosanus. Japanese Jap. J. complement. altern. med. 7, 121-124, 2010.
  • A. Honma, T. Koyama, K. Yazawa, Anti-hyperglycemic effects of sugar maple Acer saccharum and its constituent acertannin, Food Chem. 123, 390–394, 2010.
  • N. Maru, T. Koyama, O. Ohno, K. Yamada, D. Uemura, Sunabedine, a novel toxic bromotyrosine-derivative alkaloid from Okinawan sponge, order Verongida. Heterocycles, 82, 371-375, 2010.
  • A. Honma, T. Koyama, K. Yazawa, Anti-hyperglycemic effects of Japanese maple Acer amoenum leaf extract and its constituent corilagin. J. Wood Sci. 56, 507-512, 2010.
  • T. Oka, M. Fujimoto, R. Nagasaka, H. Ushio, M. Hori, H. Ozaki, Cycloartenyl ferulate, a component contained in γ-oryzanol derived from rice bran oil, attenuates mast cell degranulation, Phytomedicine, 17, 152-156 2010.


  • J.H. Choi, A. Ogawa, N. Abe, K. Masuda, T. Koyama, K. Yazawa, H. Kawagishi, Chaxines B, C, D, and E from the edible mushroom Agrocybe chaxingu. Tetrahedron, 65, 9850–9853, 2009.
  • M. Ikeuchi, T. Koyama, S. Takei, T. Kino, K. Yazawa, Effects of benzylglucosinolate on endurance capacity in mice, J. Health Sci. 55, 178-182, 2009.
  • K. Akamine, T. Koyama, K. Yazawa, Banana peel extract suppresses prostate gland enlargement in testosterone-treated mice, Biosci. Biotech. Biochem. 73, 1911-1914, 2009.
  • M. Miyata, T. Koyama, T. Kamitani, T. Toda, K. Yazawa, Anti-obesity effect on rodents of the traditional Japanese food, Tororo-kombu, shaved Laminaria. Biosci. Biotech. Biochem. 73, 2326-2328, 2009.
  • K. Ohara, A. Uchida, R. Nagasaka, H. Ushio, T. Ohshima, The effects of hydroxycinnamic acid derivatives on adiponectin secretion, Phytomedicine, 16, 130-137, 2009.
  • M.S. Islam, H. Yoshida, N. Matsuki, K. Ono, R. Nagasaka, H. Ushio, Y. Guo, T. Hiramatsum, T. Hosoya, T. Murata, M. Hori, H. Ozaki, Antioxidant, free radical scavenging and NF-κB inhibitory activities of phytosteryl ferulates: Structure-activity studies, J. Pharmacol. Sci. 111, 328-337 2009.


  • K. Masuda, M. Ikeuchi, T. Koyama, K. Yamaguchi, J.T, Woo, T. Nishimura, K. Yazawa, Suppressive effects of Anoectochilus formosanus extract on osteoclast formation in vitro and bone resorption in vivo. J. Bone Mineral Metab. 26, 123-129, 2008.
  • M. Shirosaki, T. Koyama, K. Yazawa, Anti-hyperglycemic activity of kiwifruit leaf (Actinidia deliciosa) in mice. Biosci. Biotechnol. Biochem. 72, 1099-1102, 2008.
  • M. Nishihara, M. Kamata, T. Koyama, K. Yazawa, New phospholipase A1-producing bacteria from a marine fish. Mar. Biotechnol. 10, 382-387, 2008.
  • O. Ohno, M. Ye, T. Koyama, K. Yazawa, E. Mura, H. Matsumoto, T. Ichino, K. Yamada, K. Nakamura, T. Ohno, K. Yamaguchi, J. Ishida, A. Fukamizdu, D. Uemura, Inhibitory effects of benzyl benzoate and its derivatives on angiotensin II-induced hypertension. Bioorg. Med. Chem. 16, 7843-7852, 2008.
  • 長阪玲子,篠田 明,潮 秀樹,大島敏明, 昆布に含まれるγオリザノール,日本水産学会誌,74 (1): 61-65, 2008.
  • MS Islam, T. Murata, M. Fujisawa, R. Nagasaka, H. Ushio, AM. Bari, M. Hori, Hi. Ozaki, Anti-inflammatory effects of phytosteryl ferulates in dextran sulfate sodium (DSS)-induced colitis in mice, British J. Pharmacol.154, 812-24, 2008.


  • M. Kitamura, T. Koyama, Y. Nakano, D. Uemura, Characterization of a natural inducer of coral larval metamorphosis. J. Exp. Mar. Biol. Ecol. 340, 96-102, 2007.
  • M. Ikeuchi, T. Koyama, J. Takahashi, K. Yazawa, Effects of astaxanthin in obese mice fed a high-fat diet. Biosci. Biotechnol. Biochem. 71, 893-899, 2007.
  • M. Kita, M.C. Roy, E.R.O. Siwu, I. Noma, T. Takiguchi, M. Itoh, K. Yamada, T. Koyama, T. Iwashita, D. Uemura, Durinskiol A, a long carbon-chain polyol compound from the symbiotic dinoflagellate Durinskia sp. Tetrahedron Lett. 48, 3423-3427,2007.
  • M. Kita, M.C. Roy, E.R.O. Siwu, I. Noma, T. Takiguchi, K. Yamada, T. Koyama, T. Iwashita, A. Wakamiya, D. Uemura, Relative stereochemistries of the ether rings and sugar moieties in Durinskiol A. Tetrahedron Lett. 48, 3429-3432, 2007.
  • M. Kita, N. Ohishi, K. Konishi, M. Kondo, T. Koyama, M. Kitamura, K. Yamada, D. Uemura, Symbiodinolide, a novel polyol macrolide that activates N-type Ca2+ channel from the symbiotic dinoflagellate Symbiodinium sp. Tetrahedron, 63, 6241-6251, 2007.
  • R. Nagasaka, C. Chotimarkorn, M.S. Islam, M. Hori, H. Ozaki H. Ushio, Anti-inflammatory effects of hydroxycinnamic acid derivatives. Biochem. Biophys. Res. Commun. 358, 615-619, 2007.
  • 内田麻子,大原和幸,長阪玲子,潮 秀樹, 糠漬け大根におけるγオリザノール含量, 日本調理科学会誌, 40, 184-188, 2007.


  • K. Washida, T. Koyama, K. Yamada, M. Kita, D. Uemura, Karatungiols A and B, two novel antimicrobial polyol compounds, from the symbiotic marine dinoflagellate Amphidinium sp. Tetrahedron Lett. 47, 2521-2525, 2006.
  • T. Koyama, R. Chounan, D. Uemura, K. Yamaguchi, K. Yazawa, Hepatoprotective effect of a hot-water extract from the edible thorny oyster Spondylus varius on carbon tetrachloride-induced liver injury in mice. Biosci. Biotechnol. Biochem. 70, 729-731, 2006.
  • M. Ikeuchi, K. Yamaguchi, T. Koyama, Y. Sono, K. Yazawa, Effects of fenugreek seeds (Trigonella foenum greaecum) extract on endurance capacity in mice. J. Nutr. Sci. Vitaminol. 52, 287-292, 2006.
  • M. Ikeuchi, T. Koyama, J. Takahashi, K. Yazawa, Effects of astaxanthin supplementation on exercise-induced fatigue in mice. Biol. Pharm. Bull. 29, 2106-2110, 2006.
  • R. Nagasaka, N. Okamoto, H. Ushio, Increased leptin may be involved in the short life span of ayu (Plecoglossus altivelis). J. Exp. Zool. 305, 507-512, 2006.
  • R. Nagasaka, N. Okamoto, H. Ushio, Elevated levels of oxidative DNA damage activate p53 and caspases in brain of ayu with aging. J. Appl. Ichthyol. 22, 357-362, 2006.


  • Y. Aniya, T. Koyama, C. Miyagi, M. Miyahira, C. Inomata, S. Kinoshita, T. Ichiba, Free radical scavenging and hepatoprotective actions of the medicinal herb, Crassocephalum crepidioides from the Okinawa Islands. Biol. Pharm. Bull. 28, 19-23, 2005.
  • K. Noguchi, M. Sakanashi, T. Matsuzaki, J. Nakasone, M. Sakanashi, T. Koyama, N. Hamadate, M. Sakanashi, Cardiovascular effects and lethality of venom from nematosysts of the box-jellyfish Chiropsalmus quadrigatus (Habu-kurage) in anaesthetized rats. Toxicon, 45, 519-526, 2005.
  • M. Kita, N. Ohishi, K. Washida, M. Kondo, K. Yamada, T. Koyama, D. Uemura, Symbioimine and neosymbioimine, amphoteric iminium metabolites from the symbiotic marine dinoflagellate Symbiodinium sp. Bioorg. Med. Chem. 13, 5253-5258, 2005.
  • M. Kitamura, T. Koyama, Y. Nakano, D. Uemura, Corallinafuran and corallinaether, novel toxic compounds from crustose coralline red algae. Chem. Lett. 34, 1272-1273, 2005.
  • M. Kita, M. Kitamura, T. Koyama, T. Teruya, H. Matsumoto, Y. Nakano, D. Uemura, Feeding attractants for the muricid gastropod Drupella cornus, a coral predator. Tetrahedron Lett. 46, 8583-8585, 2005.
  • R. Nagasaka, N. Okamoto, H. Ushio, Effect of caloric restriction on post-spawning death of ayu. Exp. Gerontol. 40, 556-561, 2005.
  • C. Chotimarkorn, R. Nagasaka, H. Ushio, T. Ohshima, S. Matsunaga, Development of novel fluorescent probe 3-perylene diphenylphosphine for determination of lipid hydroperoxide with fluorescent image analysis. Biochem. Biophys. Res. Commun. 338, 1222-1228, 2005.


  • T. Teruya, S. Nakagawa, T. Koyama, H. Arimoto, M. Kita, D. Uemura, Nakiterpiosin and nakiterpiosinone, novel cytotoxic C-nor-D-homosteroid from the Okinawan Sponge Terpios hoshinota. Tetrahedron, 60, 6989-6993, 2004.
  • M. Kita, M. Kondo, T. Koyama, K. Yamada, T. Matsumoto, K.H. Lee, J.T. Woo, D. Uemura, Symbioimine exhibiting inhibitory effect of osteoclast differentiation, from the symbiotic marine dinoflagellate Symbiodinium sp. J. Am. Chem. Soc. 126(15), 4794-4795, 2004.
  • R. Nagasaka, N. Okamoto, H. Ushio, Partial oxidative-stress perturbs membrane permeability for energy molecules and membrane fluidity of fish nucleated red blood cells. Comp. Biochem. Physiol. C. 13, 259-266, 2004.

Books and Review

  • 「飼料・飼育法の改善による高品質化・高付加価値化」長阪玲子『楽水百年の歩み』「第Ⅲ部 水産技術百年の歩み」5.製造 243-244ページ,2022年11月19日出版,一般社団法人 楽水会発行
  • 環境条件が導く食欲および食嗜好,日本生気象学会,2022,58,3-4号,45-49, 長阪玲子
  • 発酵美容成分の開発,第3章 抗シワ・美白・抗酸化機能(アンチエイジング機能) 「6. エルゴチオネイン」p145-153. 長阪玲子,大島敏明,シーエムシー出版,監修:尾関健二 2020年3月発行 ISBN:978-7-7813-1499-0 C3045 
  • 日本食およびその素材の健康機能性開発,第4章「貝・エビ・カニ」p159-168. 長阪玲子,シーエムシー出版,2016年5月20日発行 ISBNコード: 978-4-7813-1157-9
  • “Chapter 12, The Natural Antioxidant Ergothioneine Resources, Chemical Characterization, and Applications.” TH Nguyen, R Nagasaka, T. Ohshima, In: Lipid Oxidation: Challenges in Food Systems (A. Logan, U. Nienaber, S. Pan ed.) AOCS press, Champaign, IL, 2013, 381-415.
  • “Plant-Derived Hydroxycinnamate Derivatives, Insulin Sensitivity, and Adiponectin: Implication for Diabetes Control.” H. Ushio, K. Ohara, R. Nagasaka, M. Hori, In: Bioactive Food as Dietary Interventions for Diabetes Chapter 14 (Elsevier) (Watson RR and Preedy VR eds), 2013, 145-156.
  • “Novel Approach for Controlling Lipid Oxidation and Melanosis in Aquacultured Fish and Crustaceans: Application of Edible Mushroom (Flammulina velutipes) Extract In vivo”, A.B. Encarnacion, H.N.D. Bao, R. Nagasaka, T. Ohshima, In Aquaculture Book 1, (ed. by Z.A. Muchlisin) ISBN 978-953-307-974-5., 2012, 157-184.
  • 「第Ⅱ編,第1章,米糠に含まれる有用な生体機能物質の探索」尾崎博,堀正敏,潮秀樹,長阪玲子,『食の安全科学の展開—食のリスク予測と制御に向けて』(東京大学 食の安全研究センター編)(株)シーエムシー出版2010. 135-144.
  • 「養殖飼料への穀類糠成分オリザノールの添加効果」風間貴充,長阪玲子,潮秀樹,佐藤秀一,養殖,2009 , 1, 48-50.
  • 「米糠成分γ-オリザノールの新たな生理活性機能とその利用」長阪玲子,堀正敏,化学と生物,2009, 47, 816-818.
  • 「米抽出物γ-オリザノールおよびGABAの新たな生理作用」潮秀樹,長阪玲子,前原裕之,金本繁晴,毛利建太郎,堀正敏,美味技術研究会誌, 2008, 12, 21-25.
  • 「米糠の生活習慣病予防・改善効果」長阪玲子,潮秀樹,ジャパンフードサイエンス, 2006, 45, 72-74.